Key Reaction Competencies

We routinely develop and execute a broad portfolio of reaction types commonly required for complex small-molecule programs:

• Amidation reactions
• Halogenation chemistry
• Cyanation & nitrile transformations
• Sulfonation & sulfation processes
• Hydrogenation and selective reductions
• Asymmetric synthesis and enantioselective steps
• Enzymatic & biocatalytic transformations
• Chiral resolution and racemate separation
• C–C bond formation (cross-couplings and related coupling reactions)

Each capability is supported by tailored analytical control strategies (in-process HPLC/UPLC, PAT, LC–MS) and DoE-driven optimization to deliver consistent quality during scale-up and tech transfer.

Reagent & Catalyst Handling 

Amoli is equipped to handle a wide range of specialist reagents and catalysts used in modern API manufacturing. 

• Strong bases & organometallics: n-Butyllithium, Sodium hydride
• Hydride reductants & selective reducers
• Transition-metal catalysts: Palladium catalysts, Raney nickel
• Coupling reagents & specialty activators
• Oxidizers & peroxides (with rigorous hazard controls)
• Carbonyl-activating agents: Acetic anhydride, Triphosgene (handled under strict containment)
• Halogenation reagents: Methyl chloride and other halogen sources
• Boron-based reagents and boron chemistry
• Biocatalysts: Keto-reductases, transaminases